Indeed...
Indeed, such an observation was quite accurate, for after only a few years, a war broke out between these mightiest nations that ended with the Romans losing it, as the Holy Qur’an tells us in Chapter 30 (The Romans), which was revealed in 7 A.H./615-16 A.D., only a few months after the fall of Jerusalem to the Persians, just to win in a successive one.
Only four years prior to that date, the Persians had scored a sweeping victory over the Christians, spreading their control over Aleppo, Antioch[^2], and even Damascus. The loss of Jerusalem, birthplace of Christ Jesus son of Mary (ﻉ), was a heavy blow to the prestige of Christianity.
Most Persians were then following Zoroastrianism, a creed introduced in the 6th century before Christ by Zoroaster (628-551 B.C.), also known as Zarathustra, whose adherents are described as worshippers of the "pyre," the holy fire. "Persia," hence, meant "the land of the worshippers of the pyre, the sacred fire." Modern day Iran used to be known as "Aryana," land of the Aryan nations and tribes.
Some Persians had converted to Christianity as we know from Salman al-Farisi who was one such adherent till he fell in captivity, sold in Mecca and freed to be one of the most renown and cherished sahabis and narrators of hadith in Islamic history, so much so that the Prophet of Islam (ﻉ) said, "Salman is one of us, we (People of the Household of the Prophet)." The war referred to above was between the then Byzantine (Eastern Roman) emperor Heraclius (575 - 641 A.D.) and the Persian king Khusrau (Khosrow) Parwiz (Parviz) or Chosroes II (d.
628 A.D.). It was one of many wars in which those mighty nations were embroiled and which continued for many centuries. Yet the hands of Divine Providence were already busy paving the path for Islam: the collision between both empires paved the way for the ultimate destruction of the ancient Persian empire and in Islam setting root in that important part of the world. Moreover, Muhammad’s offspring came to marry ladies who were born and raised at Persian as well as Roman palaces.
Imam Husayn ibn Ali ibn Abu Talib (ﻉ), Muhammad’s grandson and our Third Holy Imam and father of Imam Zain al-Abidin, married the daughter of the last Persian emperor Jazdagird (Yazdegerd) III son of Shahryar and grandson of this same Khusrau II. Jazdagerd ruled Persia from 632 - 651 A.D. and lost the Battle of Qadisiyya to the Muslim forces in 636, thus ending the rule of the Sassanians for good.