It is sometimes said that it refers to their pureness of any sin...
It is sometimes said that it refers to their pureness of any sin, as Sura Anbiya, No 21, verses 26-27 say about the angels: ...Nay, they are honored servants, They do not precede Him in speech and (only) according to His commandment do they act. The term /bararah/ is the plural form of /bar/ based on /bar/ which originally means 'vastness', then, 'a vast land' is called /barr/, and since good people's generosity is vast and benefits many others, they are called /bar/.
The term 'pious' used in this verse, of course, means 'obedient to His Command' and 'sinlessness'. Thus Allah characterizes the angels in three ways: first, they are His agents for His revelations; second, they are naturally pious and honorable; and third, they are pure, obedient and sinless.
Though there are so many signs of guidance from Allah in His 'Books held (greatly) in honor' containing all kinds of reminders revealed by the angels, the ungrateful Man does not resign himself to Him, hence, it says: Cursed be man! how ungrateful is he!
The term /kufr/ may mean 'disbelief' or 'ingratitude' or 'any covering and denial of Allah', which can be suitable, here, because, in the last verses it refers to the signs of guidance and faithfulness, and in the next verses it mentions the different kinds of blessings from Allah. In any case, the objective point of Cursed be man! is to express an intensive hatred toward the ungrateful ones. Since the origin of disobedience and ungratefulness is generally pride, then to break it.
the next verse says: Of what thing did He create him? Of a sperm-drop He created him, then molded him in due proportions. Why does Man not think about the origin of his creation? Why does he forget his main source? Moreover, why does he not take note of Allah's ability in the creation of this strange creature from a sperm-drop?
If he contemplated on his creation from a sperm-drop and then, about the formation of his body and its limbs, and his faculties and abilities and even his necessities of life being in a suitable proportion, it could be the best guidance for his theological and divine knowledge. The term /qaddarahu/, 'He molded him in due proportions' is based on /taqdir/ which means 'the act of measuring and well-balancing'.
We know that there are more than twenty metals and metalloids in the human body, each of which is at a determined level from the point of quantity and quality. If these levels change to a lower or a higher degree.